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KMID : 0043319960190010071
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Archives of Pharmacal Research
1996 Volume.19 No. 1 p.71 ~ p.73
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The crystal structure of pirprofen(C3,H14,CINO2), a non-steroidal antiinflammmatory agent
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Kim Yang-Bae
Park Il-Young
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Abstract
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The molecular structure of pirprofen, 3-chloro-4-(2,5-dihydro-1H-pyrrol-1-yl)-.alpha.-methyl-benzeneacetic acid, was determined by single crystal X-ray diffraction analysis. The compound was recrystallized from a mixture of chloroform and toluene in triclinic, space group P over The calculated density is . The structure was solved by the direct method and refined by full matrix least-squares procedure to the final R value of 0.034 for 1681 independent reflections. The non-aromatic dihydropyrrol group is found to be coplanar to the central aromatic ring. The molecules are dimerized through the intermolecular hydrogen bonds at the carboxyl group in the crystal.
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KEYWORD
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Pirprofen, Antiinflammatory agent, Crystal structure, X-ray diffraction, Hydrogen bond
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